mAbs and proteins
Compare aggregation and molecular weight change under formulation, buffer, temperature, and mechanical stress conditions.
Pharma and biotech
Kinetic stability evidence for biologic development.
ARGEN is a benchtop static light scattering system that monitors aggregation, degradation, and molecular weight change across up to eight stressed samples in real time. Pharma and biotech teams use that time dimension to rank candidates before endpoint assays alone can explain the path.
Up to eight parallel SLS experiments
Thermal, chemical, and stirring stress workflows
Real-time molecular weight and stability behavior
Workflow fit
Use ARGEN where the timing of instability changes the decision.
Endpoint assays remain essential, but biologic development teams often need to know when behavior diverges, not only what changed by the endpoint. ARGEN adds a continuous SLS readout that helps teams focus orthogonal follow-up on candidates that earn it.
Advanced modalities
Support stability workflows for peptides, RNA/LNPs, AAVs, and other complex biologic systems where kinetic divergence matters.
Process and handling stress
Evaluate stirring, shear-related perturbation, temperature exposure, and condition sets that may reveal formulation weakness.
AI validation
Use physical, time-resolved evidence to pressure-test model-guided formulation hypotheses before programs commit to deeper work.
CRO and CDMO services
Turn stability testing into a higher-value client service.
CROs and CDMOs can use ARGEN to give sponsors more than an endpoint report. A kinetic stability study can show which formulation separates first, how quickly it moves, and which stress condition changed the path.
Service differentiation
Offer kinetic stability evidence as a premium add-on to formulation screening, developability, and analytical development packages.
Client decision support
Help sponsors decide what advances, what needs orthogonal follow-up, and what stress condition deserves closer inspection.
Better study design
Use early kinetic signal to narrow condition sets before running larger characterization campaigns.
Clearer technical review
Give client teams a time-resolved story they can discuss across formulation, analytical, CMC, and program leadership groups.
Proof path
Start with one formulation question.
A useful first ARGEN study is narrow.
Pick the material, stress condition, and decision threshold that matter now. Run a focused comparison, then judge whether the kinetic readout changes formulation ranking, follow-up priorities, or confidence.
- Which candidate diverges first under thermal or stirring stress?
- Which formulation keeps molecular weight behavior controlled longest?
- Which condition deserves deeper orthogonal characterization?
Next step
Pressure-test one biologic stability decision.
Use the method brief or request a discussion around a real formulation, developability, or stress-response question.