Formulation screening
Rank formulations by their stability under controlled stress.
See eight samples in parallelKinetic stability intelligence
Build biologic formulations that hold up under stress.
ARGEN delivers Kinetic Stability Intelligence through real-time measurement of aggregation onset, rate and molecular weight change under controlled stress.
Not sure whether ARGEN fits your stability question?
Start with the five-minute assessment.
The ARGEN platform
See stability change as it happens.
ARGEN provides Kinetic Stability Intelligence by monitoring molecular weight change under controlled thermal, chemical and stirring stress.
- Up to 8
- samples compared in parallel
- 3 stress modes
- thermal, chemical, and stirring
- Real-time SLS
- onset, rate, divergence, and Mw change
ARGEN platform video
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Kinetic Stability Intelligence
Eight samples. One kinetic view.
Compare when samples start to change, how quickly they aggregate and which remain stable.
Four fast, two medium, two stable.
Illustrative 24-hour study | eight parallel samples | Mw(t)/M0
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Workflow applications
Find your stability question.
Aggregation kinetics
Track aggregation onset, rate and molecular weight change.
Mechanical stress modeling
Compare formulations under stirring and shear perturbations.
View the concentration animationThermal/chemical stress
Compare temperature, pH, buffer and excipient conditions.
View temperature and pH animationsAdvanced modalities
Explore mAbs, proteins, peptides, RNA/LNPs and AAVs.
CRO/CDMO differentiation
Add stress ranking and kinetic evidence to client studies.
Industries and services
Built for pharma, food & beverage, and CRO/CDMO teams.
Pharma and biotech
Biologic formulation and developability teams
Compare biologic formulations with time-resolved SLS evidence.
Explore pharma and biotechFood and beverage
Ingredient, flavor, and shelf-life R&D
Investigate processing stress, protein functionality, flavor stability and shelf-life questions.
Explore food & beverageCRO/CDMO services
Add kinetic stability data to client programs
Give sponsors kinetic evidence for ranking and follow-up decisions.
Discuss CRO/CDMO fitResearch examples
Compare the response to stress.
Endpoint checks show the state at selected times. Continuous SLS adds onset, rate and divergence, helping focus follow-up with SEC, DLS, native PAGE and other established assays.
Stirring stress
Concentration under stirring stress
BSA | 25 °C | 500 rpm | 12 h
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Temperature and pH
Temperature-dependent aggregation
mAb | 1 mg/mL | source range 50-80 °C | 8 selected traces
Loops automatically. Tap the chart to pause or resume; Enter or Space also works.
pH-dependent molecular-weight change
BSA | 55 °C | logarithmic time in hours
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Workflow fit
From study question to next decision.
Choose the stress conditions, compare the kinetic paths and focus deeper characterization where it matters.
01
Frame the formulation question
Define candidates, stress conditions and the decision threshold.
02
Run parallel stress experiments
Compare up to eight samples under controlled stress.
03
Read the kinetic signal
Read onset, rate, divergence and molecular weight change.
04
Rank what moves forward
Prioritize orthogonal assays and support model validation.
Evaluation confidence
Test your material before you commit.
Choose representative material and a focused condition set. Review whether the kinetic evidence answers your study question before purchase.
- 01Use your material
- 02Target one decision
- 03Review fit before purchase
Research & publications
Explore the science.
Examine the evidence.
Seven publications spanning protein aggregation, mRNA, peptide stability and equilibrium characterization.
Explore foundational SMSLS research and studies that explicitly used ARGEN.
Novartis case study
Biopharmaceutical development
Advancing biophysics: semi-automated monitoring of protein aggregation kinetics to complement development of biopharmaceutics
International Journal of Pharmaceutics · 2026 · 127621 · Online 31 October
Study finding
Automated analysis reduced operator-related variation. Three case studies examined buffer, pH and excipient choices under thermal and stirring stress.
Relevance to ARGEN
Evaluates SMSLS, the measurement approach underlying ARGEN, for protein formulation decisions. Findings apply to the studied samples and conditions.
DOI: 10.1016/j.ijpharm.2026.127621
Full text available through the publisher. Access terms may apply.
SMSLS foundation
Protein aggregation
Monitoring protein aggregation kinetics with simultaneous multiple sample light scattering
Analytical Biochemistry · 2013 · 437: 185–197
Study finding
A multi-sample prototype tracked early aggregation of two monoclonal antibodies across temperature and concentration conditions, revealing distinct kinetic regimes.
Relevance to ARGEN
Foundational work on the SMSLS method underlying ARGEN; the paper describes a research prototype.
Full text available through the publisher. Access terms may apply.
SMSLS foundation
Methods & stress testing
Simultaneous Multiple Sample Light Scattering (SMSLS) for Continuous Monitoring of Protein Aggregation
ACS Symposium Series · 2015 · 1202, Chapter 6: 159–188
Study finding
This book chapter describes continuous monitoring of NISTmAb and industrial antibodies under thermal and stirring stress, including air–liquid interface effects.
Relevance to ARGEN
Explains the method and experimental approach. Its 16-cell prototype is not a specification for the current ARGEN configuration.
DOI: 10.1021/bk-2015-1202.ch006
Full text available through the publisher. Access terms may apply.
ARGEN study
mRNA stability
Consequences of mRNA Secondary Structure on Stability against both Hydrolysis and Aggregation: The Role of Electrostatic, π–π Stacking, and Thermal Effects
ACS Omega · 2026 · 11(3): 4440–4456
Study finding
Studies of free mRNA linked secondary structure to resistance against hydrolysis and aggregation, with responses varying by RNA and solution conditions.
Relevance to ARGEN
Methods explicitly use ARGEN for static light scattering alongside DLS and a custom dialysis device. This is free-mRNA research, not LNP formulation validation.
© 2026 The Authors. Published by American Chemical Society.
Licensed under CC BY 4.0.
Thumbnail: reduced-size article opening page. PDF unchanged.
ARGEN study
Aggregation reproducibility
On the Reproducibility of Early-Stage Thermally Induced and Contact-Stir-Induced Protein Aggregation
The Journal of Physical Chemistry B · 2018 · 122(40): 9361–9372
Study finding
For BSA and one monoclonal antibody, thermal aggregation was reproducible within instrumental error, while contact-stir aggregation showed greater variability.
Relevance to ARGEN
Uses ARGEN to distinguish measurement uncertainty from variability in the aggregation process under the tested conditions.
Full text available through the publisher. Access terms may apply.
ARGEN + custom method
Equilibrium characterization
Automatic, single-sweep, cuvette-based determination of A₂ (B₂₂), Kᴅ, and other equilibrium properties for macromolecules
Measurement Science and Technology · 2026 · 37: 305701
Study finding
An automatic continuous-dilution method measured concentration-dependent properties of proteins and polysaccharides in a single cuvette.
Relevance to ARGEN
ARGEN supplied static-scattering measurements of molar mass and A₂. Kᴅ came from a separate DLS instrument; the study used custom dilution hardware.
© 2026 The Authors. Published by IOP Publishing Ltd.
Licensed under CC BY 4.0.
Thumbnail: reduced-size article opening page. PDF unchanged.
ARGEN study
Peptide stability
Anisotropic Electrostatics in the Instability of GLP-1 Analog Micelles: Effects of Electrolytes, Denaturants, pH, and Temperature
ACS Omega · 2026 · 11: 49381–49401
Study finding
Liraglutide and semaglutide experiments linked aggregation to electrolyte-dependent electrostatic interactions and mapped responses to denaturant and pH.
Relevance to ARGEN
Uses ARGEN static light scattering alongside DLS and custom dialysis to investigate GLP-1 analog solution stability.
© 2026 The Authors. Published by American Chemical Society.
Licensed under CC BY 4.0.
Thumbnail: reduced-size article opening page. PDF unchanged.
Findings apply to each study’s samples, methods and conditions. Research instruments and custom accessories may differ from the current commercial configuration. Open-access PDFs and previews are credited under CC BY 4.0. Other publications link to their publisher records. Inclusion does not imply endorsement by the authors or publishers.
Explore the publications library →Kinetic stability resources
Choose your next step.
Featured webinar 30 min
Novartis scientists on aggregation kinetics
High-throughput kinetic evaluation in formulation development. Registration on Yokogawa.
Interactive assessment
ARGEN Study-Fit Assessment
Check whether ARGEN fits your study before planning the experiment.
- Formulation
- Storage
- Process stress
Method brief
Kinetic Stability Intelligence Brief
Review the method for one formulation or developability decision.
Get the brief
Studies & applications
Explore the evidence by topic.
Technical note
RNA stability monitoring
Thermal-stress RNA monitoring across buffer systems.
Read RNA noteCase study
Stirring stress aggregation
Concentration-dependent aggregation under stirring stress.
Read stirring studyIndustry case
Food and beverage stability
Flavor, protein, oxygen and shelf-life applications.
Review food and beverage caseApplications & service
Start with a practical ARGEN question.
Ask about applications, specifications, studies or service. The assistant uses approved ARGEN evidence and routes questions to the team when needed.
Start discussion
Bring one real stability question.
Tell us about your stability question.
View the ARGEN product page